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Down syndrome is a chromosomal condition that is associated with intellectual disability, a characteristic facial appearance, and weak muscle tone hypotonia in infancy. All affected individuals experience cognitive delays, but the intellectual disability is usually mild to moderate.

People with Down syndrome may have a variety of birth defects. About half of all affected children are born with a heart defect. Digestive abnormalities, such as a blockage of the intestine, are less common. Individuals with Down syndrome have an increased risk of developing several medical conditions. These include gastroesophageal reflux, which is a backflow of acidic stomach contents into the esophagus, and celiac diseasewhich is an intolerance of a wheat protein called gluten.

About 15 percent of people with Down syndrome have an underactive thyroid gland hypothyroidism. The thyroid gland is Sex with down syndrome butterfly-shaped organ in the lower neck that produces hormones.

Individuals with Sex with down syndrome syndrome also have an increased risk of hearing and vision problems. Additionally, a small percentage of children with Down syndrome develop cancer of blood-forming cells leukemia. Delayed development and behavioral problems are often reported in children with Down syndrome.

Affected individuals' speech and language develop later and more slowly than in children without Down syndromeand affected individuals' speech may be more difficult to understand. A small percentage of people with Down syndrome are also diagnosed with developmental conditions called autism spectrum disorders, which affect communication and social interaction.

People with Down syndrome often experience a gradual decline in thinking ability cognition as they age, usually starting around age Down syndrome is also associated with an increased risk of developing Alzheimer diseasea brain disorder that results in a gradual loss of memory, judgment, and ability to function.

Approximately half of adults with Down syndrome develop Alzheimer disease. Although Alzheimer disease is usually a disorder that occurs in older adults, people with Down syndrome usually develop this condition in their fifties or sixties.

Down syndrome occurs in about 1 in newborns. About 5, babies with Down syndrome are born in the United States each year, and approximatelypeople in this country have the condition. Although women of any age can have a child with Down syndromethe chance of having a child with this condition increases as a woman gets older. Most cases of Down syndrome result from trisomy 21which means each cell Sexy black girls hairy pussy the body has three copies of chromosome 21 instead of the usual two copies.

Less commonly, Down syndrome occurs when part of chromosome 21 becomes attached translocated to another chromosome during the formation of reproductive cells eggs and sperm in a parent or very early in fetal development. Affected people have two normal copies of chromosome 21 plus extra material from chromosome 21 attached to another chromosome, resulting in three copies of genetic material from chromosome Affected Sex with down syndrome with Sex with down syndrome genetic change are said to have translocation Down syndrome.

A very small percentage of people with Down syndrome have an extra copy of chromosome 21 in only some of the body's cells. In these people, the condition is called mosaic Down syndrome. Sex with down syndrome believe that having extra All naruto girls naked of genes on chromosome 21 disrupts the course of normal development, causing the characteristic features of Down syndrome and the increased risk of health problems associated with this condition.

Most cases of Down syndrome are not inherited. When the condition is caused by trisomy 21, the chromosomal abnormality occurs as a random event during the formation of reproductive cells in a parent. The abnormality usually occurs in egg cells, but it occasionally occurs in sperm cells.

An error in cell division called nondisjunction results in a reproductive cell with an abnormal number of chromosomes. For example, an egg or sperm cell may gain an extra copy of chromosome If one of these atypical reproductive cells contributes to the genetic makeup of a child, the child will have an extra chromosome 21 in each of the body's cells.

People with translocation Down syndrome can inherit the condition from an unaffected parent. The parent carries a rearrangement Sex with down syndrome genetic material between chromosome 21 and another chromosome. This rearrangement is called a balanced translocation. No genetic material is gained or lost in a balanced translocation, so these chromosomal changes usually do not cause any health problems.

However, as this translocation is passed to the next generation, it can become unbalanced. People who inherit an unbalanced translocation involving chromosome 21 may have extra genetic material from chromosome 21which causes Down syndrome. Like trisomy 21, mosaic Down syndrome is not inherited.

It occurs as a random event during cell division early in fetal development. As a result, some of the body's cells have the usual two copies of chromosome 21and other cells have three copies of this chromosome. Chromosome 21 and down syndrome: from genomics to pathophysiology. Nat Rev Genet.

Neurobehavioral disorders in children, adolescents, and young adults Sex with down syndrome Down syndrome. Autistic-spectrum disorders in Down syndrome: further delineation and distinction from other behavioral abnormalities.

Behavioral phenotype of individuals with Down syndrome. Cohen WI. Current dilemmas in Down syndrome clinical care: celiac disease, thyroid disorders, and atlanto-axial instability. Kumin L. Speech intelligibility and childhood verbal apraxia in children with Down syndrome. Downs Syndr Res Pract. Lott IT, Head Julie andrews having sex. Alzheimer disease and Down syndrome: factors in pathogenesis.

Neurobiol Aging. Lubec G, Engidawork E. J Neurol. Shapiro BL. Down syndrome and associated congenital malformations. J Neural Transm Suppl. Epidemiology of Down syndrome. Developmental disabilities grown up: Down syndrome. J Dev Behav Pediatr. Alzheimer's disease in Down syndrome: neurobiology and risk. Estimates of the live births, natural losses, Sex with down syndrome elective terminations Sex with down syndrome Down syndrome in the United States.

Am J Sex with down syndrome Genet A. Estimation of the number of people with Down syndrome in the United States. Genet Med.

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